Adenosine | 58-61-7

Adenosine, nucleoside e entsoeng ka adenine le ribose, e na le lits'ebetso tse 'maloa tsa bohlokoa ho tsa bongaka le physiology ka lebaka la litlamorao tsa eona tsa 'mele lits'ebetsong tse fapaneng tsa' mele.

Meriana ea pelo:

Sesebelisoa sa Tlhahlobo: Adenosine e sebelisoa e le moemeli oa khatello ea meriana nakong ea liteko tsa khatello ea pelo, joalo ka litšoantšo tsa myocardial perfusion. E thusa ho hlahloba lefu la methapo ea pelo ka ho susumetsa methapo ea pelo, ho etsisa liphello tsa boikoetliso ba 'mele.

Kalafo ea Supraventricular Tachycardia (SVT): Adenosine ke meriana ea pele ea ho felisa likarolo tsa SVT. E sebetsa ka ho fokotsa ho khanna ka node ea atrioventricular, ho sitisa litsela tse khutlelang morao tse ikarabellang bakeng sa SVT.

Neurology:

Taolo ea ho Sebetsa: Adenosine ke anticonvulsant e sa feleng bokong. Ho feto-fetoha ha li-adenosine receptors ho ka ba le litlamorao tse thibelang lefu la sethoathoa, 'me ho ntse ho etsoa lipatlisiso ka li-adenosine-release agents e le liphekolo tse ka bang teng bakeng sa sethoathoa.

Neuroprotection: Li-receptor tsa Adenosine li bapala karolo ea ho sireletsa methapo ea kutlo ho tsoa kotsi ea ischemic le khatello ea oxidative. Patlisiso e lekola bokhoni ba adenosine joalo ka ntho e sireletsang methapo ea kutlo mafung a stroke le a neurodegenerative joalo ka Parkinson's le Alzheimer's.

Moriana oa ho Phefumoloha:

Bronchodilation: Adenosine e sebetsa joalo ka bronchodilator mme e sebelisoa tlhahlobong ea bronchoprovocation ho hlahloba asma. E etsa hore ho be le bronchoconstriction ho batho ba nang le asthma, ho thusa ho lemoha hyperreactivity ea moea.

Litšobotsi tsa Antiarrhythmic:

Adenosine e ka hatella mefuta e itseng ea arrhythmias ka ho fetola tšebetso ea motlakase pelong, haholo-holo sebakeng sa atria le atrioventricular node. Nako e khutšoanyane ea halofo ea bophelo e fokotsa liphello tsa tsamaiso.

Sesebediswa sa Patlisiso:

Adenosine le li-analogues tsa eona li sebelisoa haholo lipatlisisong ho ithuta karolo ea li-receptor tsa adenosine lits'ebetsong tse fapaneng tsa 'mele le tsa pathological. Li thusa ho hlakisa mesebetsi ea adenosine ho neurotransmission, karabelo ea 'mele ea ho itšireletsa mafung, ho ruruha le taolo ea pelo.

Likopo tse ka 'nang tsa etsahala tsa Phekolo:

Lithethefatsi tse thehiloeng ho Adenosine li ntse li etsoa lipatlisiso bakeng sa ts'ebeliso ea kalafo e ka bang teng maemong a kang mofetše, kotsi ea ischemic, taolo ea bohloko le mathata a ho ruruha. Adenosine receptor agonists le bahanyetsi ke tse ling tsa metsoako e ithutoang.