Fludarabine | 21679-14-1

Fludarabine ke meriana ea chemotherapy e sebelisoang haholo ho phekola mefuta e itseng ea mofetše, haholo-holo malignancies a hematological. Mona ke kakaretso:

Mokhoa oa Ts'ebetso: Fludarabine ke analog ea nucleoside e sitisang motsoako oa DNA le RNA. E thibela DNA polymerase, DNA primase, le DNA ligase enzymes, e lebisang ho robeheng ha strand ea DNA le ho thibela mekhoa ea ho lokisa DNA. Tšitiso ena ea motsoako oa DNA qetellong e baka apoptosis (lefu la sele e hlophisitsoeng) liseleng tse arohaneng ka potlako, ho kenyeletsoa lisele tsa mofetše.

Lipontšo: Fludarabine e atisa ho sebelisoa ho phekola lefu le sa foleng la lymphocytic leukemia (CLL), hammoho le malignancies a mang a hematological a kang indolent non-Hodgkin lymphoma le mantle cell lymphoma. E ka boela ea sebelisoa maemong a itseng a acute myeloid leukemia (AML).

Tsamaiso: Fludarabine e atisa ho tsamaisoa ka intravenously (IV) sebakeng sa kliniki, le hoja e ka boela ea fanoa ka molomo maemong a mang. Tekanyetso le kemiso ea tsamaiso li itšetlehile ka mofetše o itseng o phekoloang, hammoho le bophelo bo botle ba mokuli ka kakaretso le tsela eo a arabelang ka eona kalafo.

Liphello tse mpe: Litla-morao tse tloaelehileng tsa fludarabine li kenyelletsa khatello ea masapo (e lebisang ho neutropenia, phokolo ea mali, le thrombocytopenia), ho nyekeloa ke pelo, ho hlatsa, letšollo, feberu, mokhathala, le ho eketseha ha ts'oaetso ea tšoaetso. E ka boela ea baka litlamorao tse mpe tse matla joalo ka neurotoxicity, hepatotoxicity, le chefo ea pulmonary maemong a mang.

Litlhokomelo: Fludarabine e hanyetsanoa ho bakuli ba nang le khatello e matla ea masapo kapa mosebetsi oa renal o sa sebetseng hantle. E lokela ho sebelisoa ka hloko ho bakuli ba nang le lefu la sebete kapa liphio, hammoho le bakhachane kapa ba anyesang ka lebaka la monyetla oa ho ntša kotsi ho lesea kapa lesea.

Litšebelisano tsa Lithethefatsi: Fludarabine e ka sebelisana le meriana e meng, haholo-holo e amang moko oa masapo kapa mosebetsi oa renal. Ho bohlokoa hore bafani ba tlhokomelo ea bophelo bo botle ba hlahlobe lethathamo la meriana ea mokuli ka hloko le ho lekola litšebelisano tse ka bang teng tsa lithethefatsi.

Tlhokomelo: Ho beha leihlo khafetsa lipalo tsa mali le ts'ebetso ea renal ho bohlokoa nakong ea kalafo le fludarabine ho lekola matšoao a khatello ea moko oa masapo kapa litlamorao tse ling tse mpe. Litokiso tsa lethal dose li ka hlokahala ho ipapisitsoe le liparamente tsena tsa tlhahlobo.