Tacrolimus | 104987-11-3

Tacrolimus, e tsejoang hape ka lebitso la eona la khoebo Prograf har'a tse ling, ke sethethefatsi se matla sa immunosuppressive se sebelisoang haholo ho fetisoa ha setho ho thibela ho hana.

Mokhoa oa Ts'ebetso: Tacrolimus e sebetsa ka ho thibela calcineurin, protheine phosphatase e bapalang karolo ea bohlokoa ts'ebetsong ea li-T-lymphocyte, e leng lisele tsa 'mele tsa ho itšireletsa mafung tse amehang ho hanetsoeng hoa graft. Ka ho thibela calcineurin, tacrolimus e thibela tlhahiso ea li-cytokine tsa pro-inflammatory le ho thibela ts'ebetso ea lisele tsa T, kahoo e hatella karabelo ea 'mele ea ho itšireletsa mafung khahlanong le setho se fetisitsoeng.

Lipontšo: Tacrolimus e bontšoa bakeng sa prophylaxis ea ho hana litho tsa 'mele ho bakuli ba fumanang li-allogeneic sebete, liphio kapa li-transplant tsa pelo. Hangata e sebelisoa hammoho le lisebelisoa tse ling tsa immunosuppressive tse kang corticosteroids le mycophenolate mofetil.

Tsamaiso: Tacrolimus hangata e tsamaisoa ka molomo ka mokhoa oa li-capsules kapa tharollo ea molomo. E ka boela ea fanoa ka methapo maemong a itseng a kliniki, joalo ka nakong ea hang-hang ka mor'a ho fetisoa.

Tlhokomelo: Ka lebaka la index ea eona e patisaneng ea kalafo le ho fapana ha ho monya, tacrolimus e hloka tlhahlobo e hlokolosi ea maemo a mali ho netefatsa katleho ea kalafo ha e ntse e fokotsa kotsi ea chefo. Tlhokomelo ea lithethefatsi ea kalafo e kenyelletsa ho lekanya khafetsa maemo a mali a tacrolimus le tokiso ea lethal dose ho latela maemo ana.

Litlamorao tse mpe: Litla-morao tse tloaelehileng tsa tacrolimus li kenyelletsa nephrotoxicity, neurotoxicity, khatello e phahameng ea mali, hyperglycemia, mathata a ka mpeng, le monyetla o eketsehileng oa ho tšoaetsoa mafu. Tšebeliso ea nako e telele ea tacrolimus e ka boela ea eketsa kotsi ea ho ba le maloetse a itseng, haholo-holo kankere ea letlalo le lymphoma.

Litšebelisano tsa Lithethefatsi: Tacrolimus e sebelisoa haholo ke cytochrome P450 enzyme system, haholo-holo CYP3A4 le CYP3A5. Ka hona, lithethefatsi tse susumetsang kapa tse thibelang li-enzyme tsena li ka ama maemo a tacrolimus 'meleng, tse ka lebisang ho hloleheng ha kalafo kapa chefo.

Mehopolo e Khethehileng: Tacrolimus dosing e hloka motho ka mong ho latela lintlha tse kang lilemo tsa mokuli, boima ba 'mele, ts'ebetso ea renal, meriana e ts'oanang le ho ba teng ha mafu a kopaneng. Tlhokomelo e haufi-ufi le ho latela khafetsa le bafani ba tlhokomelo ea bophelo bo botle ho bohlokoa bakeng sa ho ntlafatsa kalafo le ho fokotsa litlamorao tse mpe.