Conotoxin |129129-65-3

Li-conotoxins ke sehlopha se fapaneng sa chefo e nyane ea peptide e hlahisoang ke likhofu tsa kholu (mofuta oa Conus).Likhofu tsena tsa metsing li fumaneha maoatleng a tropike le a tropike 'me li tsebahala ka mokhoa o ikhethang oa ho tsoma.Likhofu tsa li-cone li sebelisa chefo ho thibela phofu ea tsona, eo haholo-holo e nang le likokoana-hloko tse ling tse kang litlhapi le liboko.

Li-conotoxins li fumaneha chefong ea likhofu tsa likhofu 'me li sebeletsa merero e fapaneng, joalo ka ho kokobetsa phofu le ho itšireletsa khahlanong le libatana.Li-peptide tse ka har'a li-conotoxin li na le mefuta e mengata ea mesebetsi ea meriana 'me li ka sebelisana le li-receptor tse khethehileng le likanale tsa ion tsamaisong ea methapo.Ka lebaka la maemo a bona a holimo bakeng sa lipheo tse itseng, li-conotoxin li hohetse tlhokomelo ho tsoa ho bafuputsi bakeng sa ts'ebeliso ea tsona ea bongaka le nts'etsopele ea lithethefatsi.

Li-conotoxins li arotsoe ka malapa a 'maloa ho latela sebopeho sa tsona le li-receptor tse shebiloeng tseo ba sebelisanang le tsona.Malapa a mang a kenyelletsa:

A-conotoxins: Sepheo sa li-receptor tsa nicotinic acetylcholine.

M-conotoxins: Thibela likanale tsa sodium tse nang le voltage-gated.

O-conotoxins: Ho sebelisana le likanale tsa khalsiamo tsa voltage-gated.

T-conotoxins: Likanale tsa potasiamo tse hahelletsoeng ka motlakase.

Lintho tsena tse chefo li bontšitse tšepiso tlhahisong ea meriana e mecha bakeng sa ho laola bohloko, mafu a methapo ea kutlo le maemo a mang a bongaka.Bo-ramahlale ba thahasella haholo bokhoni ba bona ba ho khetha li-receptor tse itseng, ho li etsa hore li be bohlokoa moralong oa litlhare tse lebisitsoeng ho feta tse sebetsang hantle.

Sephutheloana:25KG/BAG kapa kamoo o kopang kateng.

Polokelo:Boloka sebakeng se nang le moea oa moea, se omileng.

PhethahatsoTloaelo:Maemo a Machaba.